To create a reference from a website, you must use EndNote Online in conjunction with EndNote Desktop.
First you have to download the installer:
Step 1: In EndNote Online select the Options tab and then click Download Installers.
Step 2: Drag the Capture Reference button to your bookmark bar or right click on the button and add it to the bookmark bar. A Firefox extension is also available.
To create a reference from a website:
Step 1: Click the Capture Reference button in your bookmark bar while on the desired website.
Step 2: Select EndNote.
Step 3: Change the Reference Type to Web Page.
Step 4: Click Save to.
Step 5: A window indicating the reference was successfully captured will pop up.
Step 6: Select the application with which to open the .ris file by clicking on Browse.
Step 7: Choose Endnote X7 from the Helper Application menu and click OK.
Step 8: Click OK in the Capture To Desktop and the reference will appear in the Imported References folder in your EndNote Desktop library.